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DiscoverX PathHunter™ CXCR3 Activated GPCR Internalization U2OS Cell Line

Codice prodotto. 17373609
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Quantità:
2 Vials
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Codice prodotto. Quantità
17373609 2 Vials
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Codice prodotto. 17373609 Fornitore DiscoverX N. del fornitore 930661C3

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Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso

Descrizione

The PathHunter™ CXCR3 Activated GPCR Internalization U2OS Cell Line measures CXCR3 (GPCR) internalization via early-endosome localization. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ CXCR3 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line enables assessment of ligand (e.g. CXCL11/I-TAC) based internalization of CXCR3 via detection of localization to the early endosome. This product uses EFC technology. The included cell line overexpresses EA-tagged β-arrestin 2 as well as a PK-tagged early endosome protein and untagged CXCR3. Upon ligand-induced receptor activation, β-arrestin 2 is recruited to the activated GPCR and the resulting CXCR3-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifica

Assay Entry Receptor Internalization
Linea cellulare U2OS
Formato 2 vials
Da utilizzare con (applicazione) Cell Lines
Primary Agonist Recombinant Human I-TAC (CXCL11)
Quantità 2 Vials
Target Entry CXCR3
Numero di accesso AY242128
Titolo del prodotto
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