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DiscoverX PathHunter™ HTR2C Activated GPCR Internalization U2OS Cell Line

Codice prodotto. 17383619
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Quantità:
2 Vials
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Codice prodotto. Quantità
17383619 2 Vials
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Codice prodotto. 17383619 Fornitore DiscoverX N. del fornitore 930669C3

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Descrizione

The PathHunter™ HTR2C Activated GPCR Internalization U2OS Cell Line measures HTR2C (GPCR) internalization via early-endosome localization. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ HTR2C Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line enables assessment of ligand (e.g. serotonin/5-HT) based internalization of HTR2C via detection of localization to the early endosome. This product uses EFC technology. The included cell line overexpresses EA-tagged β-arrestin 2 as well as a PK-tagged early endosome protein and untagged HTR2C. Upon ligand-induced receptor activation, β-arrestin 2 is recruited to the activated GPCR and the resulting HTR2C-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifica

Assay Entry Receptor Internalization
Linea cellulare U2OS
Da utilizzare con (applicazione) Cell Lines
Primary Agonist Serotonin/5-HT
Quantità 2 Vials
Target Entry HTR2C
Numero di accesso NM_000868.2
Titolo del prodotto
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