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DiscoverX PathHunter™ U2OS ErbB2-ErbB3 Functional Assay

Codice prodotto. 17303359
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Quantità:
2 Vials
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Codice prodotto. Quantità
17303359 2 Vials
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Codice prodotto. 17303359 Fornitore DiscoverX N. del fornitore 930535C3

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Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso

Descrizione

The PathHunter™ U2OS ErbB2-ErbB3 Functional Assay measures ErbB2-ErbB3 receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ U2OS ErbB2-ErbB3 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated ErbB2 and ErbB3 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged ErbB2 and an EA-tagged SH2 domain protein. It also overexpresses an untagged coreceptor, ErbB3 Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifica

Assay Entry Receptor Activation
Linea cellulare U2OS
Da utilizzare con (applicazione) Cell Lines
Primary Agonist Recombinant Human Heregulinβ-1
Quantità 2 Vials
Target Entry ErbB2-ErbB3
Numero di accesso NM_004448.2
Titolo del prodotto
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