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DiscoverX PathHunter™ U2OS FGFR1-β-Klotho Functional Assay

Codice prodotto. 17314399
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Quantità:
2 Vials
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Codice prodotto. Quantità
17314399 2 Vials
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Codice prodotto. 17314399 Fornitore DiscoverX N. del fornitore 931118C3

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Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso

Descrizione

The PathHunter™ U2OS FGFR1-β-Klotho Functional Assay measures FGFR1-β-Klotho receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ U2OS FGFR1-β-Klotho Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated FGFR1 and β-Klotho dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged FGFR1 and an EA-tagged SH2 domain protein. It also overexpresses an untagged coreceptor, β-Klotho Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifica

Assay Entry Receptor Phosphorylation
Linea cellulare U2OS
Da utilizzare con (applicazione) Cell Lines
Primary Agonist FGF-21
Quantità 2 Vials
Target Entry FGFR1-β-Klotho
Numero di accesso NM_001174063
Titolo del prodotto
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