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DiscoverX PathHunter™ U2OS mRHO(P23H) MEM-EA Pharmacotrafficking Assay

Codice prodotto. 17374349
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Quantità:
2 Vials
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Codice prodotto. Quantità
17374349 2 Vials
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Codice prodotto. 17374349 Fornitore DiscoverX N. del fornitore 931077C3

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Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso

Descrizione

The PathHunter™ U2OS mRHO(P23H) MEM-EA Pharmacotrafficking Assay measures pharmacochaperone-based stabilization of mutant mRHO GPCR via detection of localization to the membrane. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ U2OS mRHO(P23H) MEM-EA Pharmacotrafficking Assay is a stable, engineered cell line for use in studying pharmacochaperones targeting mRHO. This cell line enables assessment of chaperone-based stabilization of mRHO(P23H) via detection of rescued membrane trafficking. This product uses EFC technology. The included cell line overexpresses PK-tagged mutant mRHO(P23H), which is misfolded and retained in the ER. The cell line also expresses membrane-localized EA. When a pharmacochaperone stabilizes the mutant mRHO, it is trafficked to the membrane, producing EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifica

Assay Entry Pharmacotrafficking
Linea cellulare U2OS
Da utilizzare con (applicazione) Cell Lines
Primary Agonist 9-cis-Retinal
Quantità 2 Vials
Target Entry mRHO(P23H)
Numero di accesso NM_145383.1
Titolo del prodotto
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