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Thermo Scientific™ pH Gradient Buffers
Robust reproducible gradients that are applicable to a wide range of MAbs and ready to use with existing LC columns and systems, without the need to formulate mobile phases.
Marca: Thermo Scientific™ 085349
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Description
Obtain fast and highly robust, reproducible HPLC gradients using Thermo Scientific™ CX-1 pH Gradient Buffers. Simple to optimize and easily automated, these buffers are applicable for HPLC separation of the majority of monoclonal antibody (mAb) biotherapeutics drugs. CX-1 pH Gradient Buffers are ready to use with existing HPLC columns without the need to formulate mobile phases. The CX-1 buffers save time in method development, facilitate method transfer to QA/QC for a wide range of mAb charge variants through a generic HPLC-based approach to mAb characterization, and do not require time-consuming mobile phase adjustments.
pH buffer solutions can be used to generate highly reproducible, linear pH gradients in cation exchange chromatography.
- Robust, reproducible gradients
- Predict biomolecule pH
- Simple method optimization
- Easily automated
- Applicable to the majority of MAbs
Unlike traditional cation exchange chromatography using salt gradients, it is possible to predict the pH and the expected retention of the charge variants and use a narrow pH range to get a higher resolution separation.
Specifications
| CX-1 pH Gradient Buffer Kit; 250 mL Buffer A + 250 mL Buffer B |
|
| Thermo Scientific | |
| 250 mL | |
| 250 mL + 250 mL |
| LC Columns and Systems | |
| CX-1 pH Gradient Buffer Kit | |
| 5.6 to 10.2 |
Safety and Handling
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
Supplemental information
- pH gradient buffer set
Signal Word
- Attenzione
Hazard Category
- Lesione oculare grave/irritazione oculare Categoria 2
- Corrosione/irritazione della pelle Categoria 2
Hazard Statement
- H315-Provoca irritazione cutanea.
- H319-Provoca grave irritazione oculare.
Precautionary Statement
- P264-Lavare accuratamente dopo l'uso.
- P280-Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.
- P305+P351+P338-IN CASO DI CONTATTO CON GLI OCCHI: sciacquare accuratamente per parecchi minuti. Togliere le eventuali lenti a contatto se è agevole farlo. Continuare a sciacquare.
- P332+P313-In caso di irritazione della pelle: consultare un medico.
- P337+P313-Se l'irritazione degli occhi persiste, consultare un medico.
Supplemental information
- MIXTURE LIST-Contiene: 2-(N-Morpholino)ethanesulfonic acid (MES), 3-(N-Morpholino)propanesulphonic acid(MOPS), N-[Tris(hyd