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Invitrogen™ Phospho-Elk1 (Ser383) Polyclonal Antibody
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Codice prodotto. 16691275
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Quantità:
100 μL
Dimensione della confezione:
100µL
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Codice prodotto. Quantità unitSize
16691275 100 μL 100µL
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Codice prodotto. 16691275 Fornitore Invitrogen™ N. del fornitore PA5104832

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Descrizione

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of ELK1 only when phosphorylated at Serine 383.

ELK1 is a component of the ternary complex that binds the serum response element (SRE) and mediates gene activity in response to serum and growth factors. ELK1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus. Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by ELK1. ELK1 appears to be a direct target of activated MAP kinase. Biochemical studies indicate that ELK1 is a good substrate for MAP kinase, the kinetics of ELK1 phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block ELK1 activation in vivo. ELK1 is a nuclear target for the ras-raf-MAPK signaling cascade. Alternatively spliced transcript variants encoding the same protein have been found for ELK1.
TRUSTED_SUSTAINABILITY

Specifica

Antigene Phospho-Elk1 (Ser383)
Applicazioni Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classificazione Polyclonal
Concentrazione 1 mg/mL
Coniugato Unconjugated
Formulazione PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ELK1
N. accesso geni A4GTP4, P19419, P41969
Alias gene ELK 1; ELK1; Elk-1; ELK1, ETS transcription factor; ELK1, member of ETS oncogene family; ETS domain-containing protein Elk-1; ETS transcription factor ELK1; ETS-like gene 1; Oncogene Elk1; tyrosine kinase (ELK1) oncogene
Simboli geni ELK1
Specie ospite Rabbit
Immunogeno A synthesized peptide derived from human ELK1(Accession P19419), corresponding to amino acid residues around phosphorylated Ser383.
Metodo di purificazione Sequential chromatography
Quantità 100 μL
Status giuridico RUO
Primario o secondario Primary
ID gene (immissione) 13712, 2002, 314436
Target Species Human, Mouse, Rat, Monkey
Content And Storage -20°C
Product Type Antibody
Forma Liquid
Isotype IgG
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