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Invitrogen™ Phospho-p27 Kip1 (Thr187) Polyclonal Antibody
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Codice prodotto. 10853801
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Quantità:
400 μL
Dimensione della confezione:
100µg
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Codice prodotto. Quantità unitSize
10853801 400 μL 100µg
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Codice prodotto. 10853801 Fornitore Invitrogen™ N. del fornitore PA512651

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Descrizione

Rabbit Polyclonal Antibody

This antibody is predicted to react with hamster based on sequence homology.

p27 Kip1 functions as a negative regulator of G1 mouse expression and has been proposed to function as a possible mediator of TGFb induced G1 arrest. p27 Kip1 is an important regulator of cell cycle progression, a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. p27 Kip1 acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. p27 Kip1 has a molecular weight of approximately 27kDa and the degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
TRUSTED_SUSTAINABILITY

Specifica

Antigene Phospho-p27 Kip1 (Thr187)
Applicazioni Immunohistochemistry (Paraffin), Western Blot
Classificazione Polyclonal
Concentrazione 0.34 mg/mL
Coniugato Unconjugated
Formulazione PBS with 0.09% sodium azide; pH 7.4
Gene Cdkn1b
N. accesso geni P46527
Alias gene AA408329; AI843786; Cdki1b; CDKN1B; CDKN4; CDN1B; cyclin dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor 1B (p27 Kip1); Cyclin-dependent kinase inhibitor 1B (p27, Kip1); cyclin-dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor p27 Kip1; cyclin-dependent kinase inhibitor p27/Kip1; KIP1; MEN1B; MEN4; p27; P27 CDKN1B; p27(KIP1); p27Kip1
Simboli geni Cdkn1b
Specie ospite Rabbit
Immunogeno KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T187 of human p27Kip1.
Metodo di purificazione Antigen Affinity Chromatography, Protein A
Quantità 400 μL
Status giuridico RUO
Primario o secondario Primary
ID gene (immissione) 1027
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Forma Liquid
Isotype IgG
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