R&D Systems™ Quantikine Immunoassay Control Set 933 for Human HS IL-17

IL-17 family is comprised of at least six proinflammatory cytokines that share conserved cysteine-knot structure but diverge at N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production, recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15, IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds IL-17B receptor, but not IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

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