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Invitrogen™ RAP80 Polyclonal Antibody

Codice prodotto. 12828472
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Quantità:
100 μg
Dimensione della confezione:
100µg
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Codice prodotto. Quantità unitSize
12828472 100 μg 100µg
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Codice prodotto. 12828472 Fornitore Invitrogen™ N. del fornitore PA520414

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Descrizione

Rabbit Polyclonal Antibody

A suggested positive control is 293 cell lysate. PA5-20414 can be used with blocking peptide PEP-0531.

RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist.
TRUSTED_SUSTAINABILITY

Specifica

Antigene RAP80
Applicazioni Immunohistochemistry, Western Blot
Classificazione Polyclonal
Concentrazione 1 mg/mL
Coniugato Unconjugated
Formulazione PBS with 0.02% sodium azide
Gene UIMC1
N. accesso geni Q5U5Q9, Q96RL1
Alias gene 9430016E08Rik; BRCA1-A complex subunit RAP80; D330018D10Rik; D630032M02Rik; RAP80; Receptor-associated protein 80; retinoid X receptor interacting protein 110; retinoid X receptor-interacting protein 110; RGD1307009; RIP110; Rxrip110; ubiquitin interaction motif containing 1; ubiquitin interaction motif-containing protein 1; Uimc1; X2HRIP110
Simboli geni UIMC1
Specie ospite Rabbit
Immunogeno A 17 amino acid peptide from near the amino terminus of human RAP80.
Metodo di purificazione Antigen affinity chromatography
Quantità 100 μg
Status giuridico RUO
Primario o secondario Primary
ID gene (immissione) 20184, 51720
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Forma Liquid
Isotype IgG
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