RY703 Mouse Anti-Human IgG, BD Horizon™

The G18-145 monoclonal antibody specifically binds to the heavy chain of human immunoglobulin G (IgG) subclasses: IgG1, IgG2, IgG3, and IgG4. It reportedly does not react with heavy chains of other human immunoglobulin isotypes. IgG is a crucial component of the humoral immune response, controlling infection and produced by plasma B-cells. It is found in extracellular fluids like blood, lymph, peritoneal, and cerebrospinal fluids. IgG monomers consist of two light and two heavy chains with two antigen binding sites. Human, mouse, and rat species have four IgG subclasses. The BD Horizon RealYellow 703 (RY703) Dye is a tandem fluorochrome with an excitation maximum (Ex Max) at 557 nm and an emission maximum (Em Max) at 703 nm. It is designed to be excited by the Yellow-Green laser (561 nm) with minimal excitation by the 488 nm Blue laser. For conventional instruments with a Yellow-Green laser (561 nm), RY703 can be used as an alternative to PE-Cy5.5.