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Invitrogen™ Ryanodine Receptor Monoclonal Antibody (C3-33)
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Codice prodotto. 11505802
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Quantità:
100 μg
Dimensione della confezione:
100µg
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Codice prodotto. Quantità unitSize
11505802 100 μg 100µg
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Codice prodotto. 11505802 Fornitore Invitrogen™ N. del fornitore MA3916

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Descrizione

Mouse Monoclonal Antibody

MA3-916 detects ryanodine receptor 2 (RyR2) and shows cross-reactivity with RyR1 in amphibian, canine, chicken, fish, guinea pig and rat tissues. MA3-916 has been successfully used in Western blot, immunohistochemical, immunofluorescence, immunocytochemistry and immunoprecipitation procedures. By Western blot, this antibody detects a 565 kDa protein representing the ryanodine receptor. In non-mammalian vertebrates, a doublet is seen at 565 kDa representing the alpha and beta isoforms of the receptor. Immunohistochemical staining of RyR in rat cardiac tissue with MA3-916 results in intense staining of the myofiber, which is consistent with sarcoplasmic reticulum localization.

The ryanodine receptor (RyR) is the channel responsible for the release of calcium from the sarcoplasmic reticulum (SR) in muscle cells and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains; the remainder of the protein, termed the 'foot' region is located in the cytoplasm between the T-tubule and the SR. The mammalian RyR is the product of three different genes: RyR-1, which is expressed predominantly in skeletal muscle and areas of the brain, RyR-2, which is expressed predominantly in the heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain, and RyR-3 which is found in smooth muscle and the brain (striatum, thalamus and hippocampus).
TRUSTED_SUSTAINABILITY

Specifica

Antigene Ryanodine Receptor
Applicazioni Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classificazione Monoclonal
Clone C3-33
Concentrazione 1 mg/mL
Coniugato Unconjugated
Formulazione PBS with 0.05% sodium azide
Gene RYR1
N. accesso geni B0LPN4, E9PZQ0, E9Q401, F1LMY4, P11716, P21817, P30957, Q92736
Alias gene 9330127I20Rik; AI528790; ARVC2; ARVD2; Ca2+ release channel; calcium release channel; cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; cardiac muscle-type ryanodine receptor; cardiac ryanodine receptor; cardiac ryanodine receptor 2; cardiac-type ryanodine receptor; CCO; central core disease of muscle; islet-type ryanodine receptor; kidney-type ryanodine receptor; LOW QUALITY PROTEIN: ryanodine receptor 1; MHS; MHS1; PPP1R137; protein phosphatase 1, regulatory subunit 137; ryanodine receptor; ryanodine receptor 1; ryanodine receptor 1 (skeletal); ryanodine receptor 1, skeletal muscle; ryanodine receptor 1-like, skeletal muscle; ryanodine receptor 2; ryanodine receptor 2 (cardiac); ryanodine receptor 2, cardiac; ryanodine receptor type 2; ryanodine receptor type II; RYDR; Ryr; RYR1; RYR-1; Ryr1l; Ryr2; RYR-2; sarcoplasmic reticulum calcium release channel; skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; skeletal muscle-type ryanodine receptor; SKRR; Type 1 ryanodine receptor; type 1-like ryanodine receptor; type 2 ryanodine receptor; unnamed protein product; VTSIP
Simboli geni RYR1, RYR2
Specie ospite Mouse
Immunogeno Canine cardiac ryanodine receptor (RyR2).
Metodo di purificazione Protein G
Quantità 100 μg
Status giuridico RUO
Primario o secondario Primary
ID gene (immissione) 100009536, 100009540, 100727848, 100731307, 114207, 20190, 20191, 396112, 403615, 421508, 606491, 6261, 6262, 689560
Target Species Amphibian, Canine, Chicken, Fish, Guinea Pig, Human, Mouse, Rabbit, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Forma Liquid
Isotype IgG1
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