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Thermo Scientific Chemicals SB 225002

Codice prodotto. 15496869
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Quantità:
5 mg
10 mg
Dimensione della confezione:
10mg
5mg
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Codice prodotto. 15496869

Marca: Thermo Scientific Chemicals J65387.MA

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Descrizione

A potent, selective and competitive antagonist of the G-protein coupled receptor CXCR2

SB 225002 is a selective non-peptide CXCR2 inhibitor which suppresses IL-8 induced neutrophil chemotaxis and margination. In addition, SB 225002 reduces MPO activity, IL-1β, MIP-2, and keratinocyte-derived chemokine (KC) levels. Further studies suggest that SB 225002 decreases the expression of vascular endothelial growth factor, inducible NOS (NO synthase), and Cox-2 (cyclooxygenase-2 proteins) in colon tissue.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 182498-32-4
Formula molecolare C13H10BrN3O4, C13H10BrN3O4
Sinonimo 1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea

Specifica

Quantità 10 mg
Descrizione Yellow
Content And Storage -30°C to -10°C
Da utilizzare con (applicazione) A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2
Peso formulazione 352.10g/mol
Sensibilità Moisture Sensitive
Solubilità Soluble to 100mM in DMSO and to 50mM in ethanol
Product Type Signal Transduction Reagent
Forma Solid
InChI Key MQBZVUNNWUIPMK-UHFFFAOYSA-N
SMILES OC1=C(NC(=O)NC2=CC=CC=C2Br)C=CC(=C1)[N+]([O-])=O
IUPAC Name 3-(2-bromophenyl)-1-(2-hydroxy-4-nitrophenyl)urea
Molecular Weight (g/mol) 352.14
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RUO – Research Use Only

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