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Thermo Scientific Chemicals SB 225002

Catalog Number p-7082458
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Quantità:
5 mg
10 mg
Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso
182498-32-4
C13H10BrN3O4
1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso
182498-32-4
C13H10BrN3O4
1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea

A potent, selective and competitive antagonist of the G-protein coupled receptor CXCR2

SB 225002 is a selective non-peptide CXCR2 inhibitor which suppresses IL-8 induced neutrophil chemotaxis and margination. In addition, SB 225002 reduces MPO activity, IL-1β, MIP-2, and keratinocyte-derived chemokine (KC) levels. Further studies suggest that SB 225002 decreases the expression of vascular endothelial growth factor, inducible NOS (NO synthase), and Cox-2 (cyclooxygenase-2 proteins) in colon tissue.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

TRUSTED_SUSTAINABILITY
Quantità 5 mg
Descrizione Yellow
Content And Storage -30°C to -10°C
Da utilizzare con (applicazione) A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2
Peso formulazione 352.10g/mol
Sensibilità Moisture Sensitive
Solubilità Soluble to 100mM in DMSO and to 50mM in ethanol
Product Type Signal Transduction Reagent
Forma Solid

RUO – Research Use Only

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