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  6. Thermo Scientific Chemicals Tacrolimus, 99+%

Thermo Scientific Chemicals Tacrolimus, 99+%

Product Code. 15455769
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Denne vare kan ikke returneres. Se returpolitik
Regulatorisk: Dette produkt falder ind under Lov om kemiske stoffer og produkter - lovbekendtgørelse nr. 1755 af 22. december 2006. Hvis det er relevant, skal kunden fremskaffe en licens før levering.
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Denne vare kan ikke returneres. Se returpolitik
Regulatorisk: Dette produkt falder ind under Lov om kemiske stoffer og produkter - lovbekendtgørelse nr. 1755 af 22. december 2006. Hvis det er relevant, skal kunden fremskaffe en licens før levering.

Beskrivelse

Tacrolimus, CAS # 104987-11-3, also known as FK-506 or fujimycin, is a macrolide compound that exhibits immunosuppressant, neuroprotective, and neuroregenerative activities and can inhibit T-cell proliferation and activation. | CAS: 104987-11-3 | C44H69NO12

Interacts with the immunophilins cyclophilin and FKBP-12.Tacrolimus is used as an immunosuppressive drug that blocks T cell proliferation in vitro. Further, it is used as a research tool in chemically induced dimerization applications.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Tacrolimus is a macrolide isolated from Streptomyces tsukubaensis, that shows immunosuppressant, neuroprotective, and neuroregenerative activities, having the ability to block T-cell proliferation and activation in response to antigenic or mitogenic stimulation

• Tacrolimus interacts with the immunophilins cyclophilin and FKBP-12. Tacrolimus binds to the FKBP-12 protein (FK506 binding protein) and forms a complex with calcium-dependent proteins. This FKBP12-FK506 complex inhibits calcineurin phosphatase activity, resulting in decreased cytokine production, inhibition of T-lymphocyte signal transduction

• Tacrolimus also inhibits the transcription for genes that encode IL-3, IL-4, IL-5, GM-CSF, and TNF, all of which are involved in the early stages of T-cell activation

• This compound can also inhibit the release of pre-formed mediators from skin mast cells and basophils and downregulate the expression of FceRI on Langerhans cells

Application

• Tacrolimus has been studied in vitro to understand its impact on neutrophil production and/or survival • It is applied to suppress the inflammation in ulcerative cells

• It is used as a research tool in chemically induced dimerization applications in biology

• It has been used in in vitro studies to investigate its effect on human monocyte-derived dentritic cells

•

TRUSTED_SUSTAINABILITY

Kemiske identifikatorer

CAS 104987-11-3
Molecular Formula C44H69NO12
Synonym FK-506; Fugimycin

Tekniske data

Quantity 50 mg
Description White to Off-white
Content And Storage -30°C to -10°C
Format Powder
For Use With (Application) Interacts with the immunophilins cyclophilin and FKBP-12
Formula Weight 804.02g/mol
Melting Point 120°C to 125°C
Solubility Freely soluble in DMSO or ethanol; Poorly soluble in water
Product Type Signal Transduction Reagent
Form Powder
Assay ≥99%
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Frequently Asked Questions (FAQs)

At what temperature should I store Tacrolimus, 99+%?

Tacrolimus should be stored in the freezer at -20 degrees Celsius.
What is the solubility of Tacrolimus, 99+%?

Tacrolimus may be dissolved in DMSO (50 mg/mL) or ethanol (50 mg/mL). This compound is very poorly soluble in water.

Sikkerhed og håndtering

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Produktidentifikator
  • Tacrolimus
 Signalord
  • Danger
 Farekategori
  • Acute toxicity Category 3
 Faresætning
  • H301-Toxic if swallowed.
 Sikkerhedssætning
  • P264-Wash face, hands and anyexposed skin thoroughly after handling.
  • P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
Supplerende oplysninger
  • MIXTURE LIST-Contain: Tacrolimus
SDS

RUO – Research Use Only

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