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Telaglenastat, MedChemExpress

Product Code. 16491277
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Product Code. 16491277 Supplier Medchem Express Supplier No. HY12248
 Articolo soggetto a restrizioni
Spedizione stimata: 07-01-2027
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Description

MedChemExpress Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inudces autophagy and has antitumor activity.

Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inudces autophagy and has antitumor activity.

Specifications

Materiale o nome chimico Telaglenastat
CAS 1439399-58-2
Colore Light Brown
Note sul grado di purezza Research
Formula molecolare C26H24F3N7O3S
Quantità 50 mg
Sinonimo CB-839
Informazioni di solubilità DMSO : 6.29 mg/mL (11.00 mM; Need ultrasonic)
SMILES O=C(NC1=NN=C(CCCCC2=NN=C(NC(CC3=CC=CC(OC(F)(F)F)=C3)=O)C=C2)S1)CC4=NC=CC=C4
Molecular Weight (g/mol) 571.57
Peso formulazione 571.57
Percent Purity 98.0%
Grado Research
Forma fisica Solid
Da utilizzare con (applicazione) Cancer-programmed cell death
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Research purposes only

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