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TFF1/pS2 Mouse, Clone: GE2 (same as R47/94), Novus Biologicals™

Codice prodotto. 18105424 Sfoglia Tutto Bio Techne Prodotti
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0.1 mg
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Codice prodotto. Quantità unitSize
18105424 0.02 mg 0.02mg
18117724 0.1 mg 0.10mg
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Codice prodotto. 18105424 Fornitore Novus Biologicals N. del fornitore NBP2342930.02MG

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Descrizione

Mouse Monoclonal Antibody

TFF1/pS2 Monoclonal specifically detects TFF1/pS2 in Human, Cynomolgus Monkey samples. It is validated for Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin.
TRUSTED_SUSTAINABILITY

Specifica

Antigene TFF1/pS2
Applicazioni Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin)
Classificazione Monoclonal
Clone GE2 (same as R47/94)
Coniugato Unconjugated
Diluizione Western Blot 0.5-1.0ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 0.5-1ug/ml, Immunoprecipitation 0.5-1ug/500ug protein lysate, Immunohistochemistry-Paraffin 0.5-1ug/ml, Immunohistochemistry-Frozen 0.5-1ug/ml, SDS-Page
Formulazione PBS with 0.05% BSA. with 0.05% Sodium Azide
N. accesso geni P04155
Alias gene BCEIbreast cancer, estrogen-inducible sequence expressed in, Breast cancer estrogen-inducible protein, breast cancer estrogen-inducible sequence, D21S21, gastrointestinal trefoil protein pS2, hP1.A, HPS2, pNR-2, Polypeptide P1.A, Protein pS2, pS2, trefoil factor 1, trefoil factor, BCE1, human pS2 induced by estrogen from human breast cancercell line M10HP1.A
Simboli geni TFF1
Specie ospite Mouse
Immunogeno Synthetic peptide of 28 amino acid residues corresponding to CFDDTVRGVPWCFYPNTIDVPPEEECEF (aa57-84) from the C-terminus of human pS2.
Peso molecolare dell'antigene 6.5 kDa
Metodo di purificazione Protein A purified
Quantità 0.02 mg
Status giuridico RUO
Disciplina di ricerca Breast Cancer, Cancer
Primario o secondario Primary
ID gene (immissione) 7031
Test di specificità It recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
Target Species Human, Primate
Content And Storage Store at 4C.
Forma Purified
Isotype IgG1 κ
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