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Thymidylate Synthase Antibody (TS106), DyLight 680, Novus Biologicals™

Codice prodotto. 18169673 Sfoglia Tutto Bio Techne Prodotti
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Quantità:
0.1 mL
Dimensione della confezione:
0.10mL
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18169673 0.1 mL 0.10mL
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Codice prodotto. 18169673 Fornitore Novus Biologicals N. del fornitore NBP234502FR

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Descrizione

Mouse Monoclonal Antibody

Thymidylate Synthase Monoclonal specifically detects Thymidylate Synthase in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.
TRUSTED_SUSTAINABILITY

Specifica

Antigene Thymidylate Synthase
Applicazioni Western Blot, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Classificazione Monoclonal
Clone TS106
Coniugato DyLight 680
Diluizione Western Blot, ELISA, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
Alias gene EC 2.1.1.45, HsT422, MGC88736, thymidylate synthase, thymidylate synthetase, TMSTsase, TSase, TSHST422
Simboli geni TYMS
Specie ospite Mouse
Immunogeno Recombinant full-length human Thymidylate Synthase protein. (Uniprot: P04818 )
Peso molecolare dell'antigene 36 kDa
Metodo di purificazione Protein A or G purified
Quantità 0.1 mL
Status giuridico RUO
Disciplina di ricerca Cancer, Cell Cycle and Replication, DNA Repair, DNA replication Transcription Translation and Splicing, Transcription Factors and Regulators, Translation Control
Primario o secondario Primary
ID gene (immissione) 7298
Test di specificità It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Target Species Human
Content And Storage Store at 4C in the dark.
Forma Purified
Isotype IgG1 κ
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