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  5. R&D Systems™ Trametinib

R&D Systems™ Trametinib

Codice prodotto. 18746376
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50 mg
Dimensione della confezione:
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Codice prodotto. Quantità Dimensione della confezione
18746376 10 mg 10mg
18755836 50 mg 50mg
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Codice prodotto. 18746376 Fornitore R&D Systems™ N. del fornitore 7709/10
  • ONLINE EXCLUSIVE PRICE
    198.00€
    186.90€ / 10mg
    Risparmia 11.10€
    5% Sconto
 Articolo soggetto a restrizioni
Spedizione stimata: 30-10-2026
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Descrizione

A Tocris product, part of R&D Systems. Potent and selective MEK inhibitor; orally bioavailable

Trametinib is a potent and selective MEK1 and MEK2 inhibitor (IC50 = 0.92 and 1.8 nM, respectively, in cell-free assays). In vitro, it inhibits the growth of human colorectal cancer cell lines expressing either B-RAF or K-RAF (IC50 values range from 0.48 to 36 nM). In vivo, it suppresses tumor growth of HT-29 and COLO205 xenografts in nude mice. Trametinib induces apoptosis. This compound is orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifica

Materiale o nome chimico N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2 H)-yl]phenyl]acetamide
CAS 871700-17-3
Quantità 10 mg
Linea di prodotti Tocris
Bersaglio MEK Inhibitors
Formula molecolare C26H23FIN5O4
Purezza 0.98
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