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Thermo Scientific Chemicals Trimethoprim

Codice prodotto. 15455319
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15445319 1 g 1g
15465319 25 g 25g
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Codice prodotto. 15455319 Fornitore Thermo Scientific Chemicals N. del fornitore J63053.06
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Descrizione

Trimethoprim, CAS # 738-70-5, is a trimethoxybenzyl-pyrimidine used as an antimicrobial. | CAS: 738-70-5 | C14H18N4O3

An antibacterial and inhibitor of formylation. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.Trimethoprim is an antibiotic involved in the treatment of urinary tract infections, middle ear infections and traveler’s diarrhea. It is associated with sulfamethoxazole and interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Furthermore, It is also used to treat and prevent Pneumocystis jiroveci pneumonia.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Trimethoprim is a synthetic pyrimidine analog that binds dihydrofolate-reductase and inhibits the synthesis of folic acid; when paired with sulfamethoxazole, its activity is enhanced
  • Trimethoprim has antibacterial and antiprotozoal properties

Applications

  • Trimethoprim inhibits the conversion of para-aminobenzoic acid (PABA) to folic acid near the end of the synthesis pathway and can be used to study related effects
  • Trimethoprim has been radiolabeled and used to trace routes of infection, and it also has been used experimentally as a fluorescent labeler to quantify dihydrofolate-reductase expression
TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 738-70-5
Formula molecolare C14H18N4O3
Sinonimo 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine

Specifica

Quantità 5 g
Descrizione White
Content And Storage 2°C to 8°C
Formato Powder
Da utilizzare con (applicazione) An antibacterial and inhibitor of formylation. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme
Peso formulazione 290.32g/mol
Punto di fusione 199°C to 203°C
Solubilità Trimethoprim is soluble in water at 0.4 mg/ml; It is also soluble in DMSO at 50 mg/ml and chloroform at 18.2 mg/ml
Product Type Signal Transduction Reagent
Forma Powder
Beilstein 625127
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Sicurezza e movimentazione

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Identificativo prodotto
  • Trimethoprim
 Avvertenza
  • Attenzione
 Categoria di pericolo
  • Tossicità acuta Categoria 4
 Indicazioni di pericolo
  • H302-Nocivo se ingerito.
 Consigli di prudenza
  • P264-Lavare accuratamente dopo l'uso.
  • P301+P330+P331-IN CASO DI INGESTIONE: sciacquare la bocca. NON provocare il vomito.
  • P312-Contattare un CENTRO ANTIVELENI/un medico/in caso di malessere.
 Informazioni supplementari
  • MIXTURE LIST-Contain: Trimethoprim
SDS

RUO – Research Use Only

Titolo del prodotto
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