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  8. Tyrphostin A23, 99%, Thermo Scientific Chemicals

Tyrphostin A23, 99%, Thermo Scientific Chemicals

Codice prodotto. 15493099
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15483099 5 mg 5mg
15403109 25 mg 25mg
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Codice prodotto. 15493099 Fornitore Thermo Scientific Alfa Aesar N. del fornitore J60308.MA
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Spedizione stimata: 07-12-2026
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Descrizione

Potent inhibitor of EGF receptor kinase activity

Tyrphostin inhibit protein tyrosine kinase and block the EGF-dependent autophosphorylation of the receptor. The inhibitors can bind to the EGF receptor kinase domain with different affinities. It also inhibits PDGFR kinase. Tyrphostin A23 has been used to inhibit agonist-induced GP IIb- IIIa activation in permeabilized platelets and in other studies to block calcium channel currents in vascular smooth muscle cells. . Tyrphostin A23 can also inhibit the internalization of (125)I-transferrin in Heb7a cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Tyrphostin inhibit protein tyrosine kinase and block the EGF-dependent autophosphorylation of the receptor. The inhibitors can bind to the EGF receptor kinase domain with different affinities. It also inhibits PDGFR kinase. Tyrphostin A23 has been used to inhibit agonist-induced GP IIb- IIIa activation in permeabilized platelets and in other studies to block calcium channel currents in vascular smooth muscle cells. . Tyrphostin A23 can also inhibit the internalization of (125)I-transferrin in Heb7a cells.

Solubility
Soluble in DMSO, ethanol, or DMF

Notes
Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, acids, heat.
TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 118409-57-7
Formula molecolare C10H6N2O2
Molecular Weight (g/mol) 186.17
Numero MDL MFCD00133899
InChI Key VTJXFTPMFYAJJU-UHFFFAOYSA-N
Sinonimo tyrphostin 23, tyrphostin a23, 3,4-dihydroxybenzylidene malononitrile, tyrphostin ag18, tyrphostin rg50810, unii-rv0gcd31oj, 2-3,4-dihydroxyphenyl methylidene propanedinitrile, 2-3,4-dihydroxybenzylidene malononitrile, alpha-cyano-3,4-dihydroxy cinnamonitrile, propanedinitrile,2-3,4-dihydroxyphenyl methylene
PubChem CID 2052
IUPAC Name 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile
SMILES C1=CC(=C(C=C1C=C(C#N)C#N)O)O

Specifica

Materiale o nome chimico Tyrphostin A23
Colore Brown to Yellow
Quantità 10 mg
Informazioni di solubilità Soluble in DMSO, ethanol, or DMF
Peso formulazione 186.17
Percent Purity 99%
Forma fisica Powder

RUO – Research Use Only

Titolo del prodotto
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