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  6. Thermo Scientific Chemicals U-73122, 95%

Thermo Scientific Chemicals U-73122, 95%

Codice prodotto. 15465189
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Codice prodotto. Quantità unitSize
15465189 1 mg 1mg
15455189 5 mg 5mg
15475189 10 mg 10mg
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Codice prodotto. 15465189 Fornitore Thermo Scientific Chemicals N. del fornitore J62898.M^
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Descrizione

It is used as a phospholipase C, phospholipase A2, and 5-LO inhibitor. It is also determined that in SK-N-SH neuroblastoma cells, U-73122 inhibits agonist-induced down-regulation of muscarinic receptors. In addition, it is a useful tool to investigate receptor-mediated PI turnover in signal transduction. U-73122 is a potent inhibitor of human neutrophil adhesion to biological surfaces (IC50 = 50 nM) as well as adhesion-dependent granule exocytosis and oxidative burst. U-73343 (sc-201422) is useful as a negative control for investigations of U-73122 phospholipase C antagonism and its cellular consequences.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Inhibitor of phospholipase C activation and inhibits the down regulation of muscarinic receptors.
TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 112648-68-7
Formula molecolare C29H40N2O3, C29H40N2O3
Sinonimo 1-[6-[((17beta)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]pyrrole-2,5-dione

Specifica

Quantità 1 mg
Descrizione Off-white
Da utilizzare con (applicazione) Inhibitor of phospholipase C activation and inhibits the down regulation of muscarinic receptors
Saggio ≥99%
Peso formulazione 464.65g/mol
Solubilità Soluble in DMSO, ethanol, or DMF at approx. 0.5mg/ml; May require heating or overnight mixing; Insoluble in water
Product Type Signal Transduction Reagent
Forma Crystalline solid
InChI Key LUFAORPFSVMJIW-ZRJUGLEFSA-N
SMILES COC1=CC=C2[C@H]3CC[C@]4(C)[C@H](CC[C@H]4[C@@H]3CCC2=C1)NCCCCCCN1C(=O)C=CC1=O
IUPAC Name 1-(6-{[(1S,3aS,3bR,9bS,11aS)-7-methoxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]amino}hexyl)-2,5-dihydro-1H-pyrrole-2,5-dione
Molecular Weight (g/mol) 464.65
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RUO – Research Use Only

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