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WNK1 Polyclonal Antibody, Invitrogen™

Codice prodotto. 11535413
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Quantità:
100 μL
Dimensione della confezione:
100µL
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Codice prodotto. Quantità unitSize
11535413 100 μL 100µL
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Codice prodotto. 11535413 Fornitore Invitrogen N. del fornitore PA116871

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Descrizione

Rabbit Polyclonal Antibody

In Western blot, this antibody recognizes the short form of WNK1, ∽190 kDa. The theoretical molecular weight of human WNK1 is ∽251 kDa and rat WNK1 is ∽230 kDa.

WNK1 serine/threonine kinase is a member of the WNK subfamily. WNK1 may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. WNK plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Also, acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, and SGK1. WNK localizes to a segment of kidney involved in salt, potassium, and pH homeostasis, the distal nephron. Mutations in the WNK gene result in Pseudohypaldosteronism and Neuropathy.

Abbreviations: AP=Affinity Purification, ChIP=Chromatin IP, CM=Confocal Microscopy, DB=Dot Blot, EIA=ELISA, EM=Electron Microscopy, FC=Flow Cytometry, GS=Gel Supershift, IC=Immunocytochemistry, IF=Immunofluorescence, IH=Immunohistology/Immunohistochemistry, IP=Immunoprecipitation, IPK=IP Kinase Assay, KA=Kinase Assay, NEUT=Neutralization, PIA=Peptide Inhibition Assay, RIA=Radioimmunossay, TCA=T Cell Activation, WB=Western Blotting, Species: Am=Amphibian, Av=Avian, B=Bovine, Ca=Cat ,Ck=Chicken, D=Dog, Dr=Deer, Ds=Drosophila, El=Elk, Fg=Frog, Fs=Fish, Ft=Ferret, G=Goat, Gp=Guinea Pig, H=Horse, Hm=Hamster, Hu=Human, K=Kangaroo, Ms=Mouse, Nhp=Non-Human Primate, O=Ovine, P=Porcine, Rb=Rabbit, Rp=Reptile, Rt=Rat, Ys=Yeast, Xn=Xenopus, (wk)=cross reacts weakly

TRUSTED_SUSTAINABILITY

Specifica

Antigene WNK1
Applicazioni Immunocytochemistry, Western Blot
Classificazione Polyclonal
Concentrazione 5 mg/mL
Coniugato Unconjugated
Formulazione PBS with 0.05% sodium azide
Gene WNK1
N. accesso geni P83741, Q9H4A3, Q9JIH7
Alias gene 6430573H23Rik; EG406236; Erythrocyte 65 kDa protein; HSAN2; HSN2; hWNK1; KDP; KIAA0344; Kinase deficient protein; MGC163339; MGC163341; mKIAA0344; p65; PPP1R167; Prkwnk1; prostate-derived sterile 20-like kinase; protein kinase lysine-deficient 1; Protein kinase with no lysine 1; protein phosphatase 1, regulatory subunit 167; PSK; Serine/threonine-protein kinase WNK1; serine/threonine-protein kinase WNK1 1; serine/threonine-protein kinase WNK1 2; With no K; WNK lysine deficient protein kinase 1; WNK lysine deficient protein kinase 1 isoform; WNK1
Simboli geni WNK1
Specie ospite Rabbit
Immunogeno A synthetic peptide sequence within the C-teminal region of human WNK1 (within the last 350 amino acids).
Metodo di purificazione Antigen affinity chromatography
Quantità 100 μL
Status giuridico RUO
Primario o secondario Primary
ID gene (immissione) 116477, 232341, 65125
Target Species Human, Mouse, Rat
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Forma Liquid
Isotype IgG
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