Invitrogen™ Acetyl-CoA Carboxylase Polyclonal Antibody

Descrizione

Positive Control: 293T, A431, HeLa, HepG2 Predicted Reactivity: Pig (94%), Chicken (83%), Sheep (94%), Rhesus Monkey (98%), Bovine (94%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.