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Beclin Mouse, Unlabeled, Clone: 20, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 612112

 vedi altre versioni di questo prodotto

Codice prodotto. 15826099

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    188.32€ / 1 set
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Descrizione

Descrizione

Autophagy is the bulk degradation of cellular proteins through the autophagosomic-lysosomal pathway. This process is important for normal cell growth, and may be disrupted in tumor cells. Beclin is a Bcl-2 binding protein that is homologous to the yeast autophagy gene, apg6/vps30. The structure of beclin includes a Bcl-2 binding coiled-coil region, and a leucine-rich nuclear export signal (NES). Beclin protein colocalizes with intracytoplasmic organelles and nuclei in normal COS7 and MCF7 cells. However, inhibition of CRM1-dependent nuclear export leads to beclin localization primarily in the nucleus. Mutation of the NES domain of beclin also prevents nuclear export, as well as suppresses beclin-mediated nutrient deprivation-induced autophagy. In addition, these beclin mutants can not inhibit in vitro clonigenicity and in vivo tumorigenicity of MCF7 cells. Beclin interaction with Bcl-2 may be involved with host viral defense, since overexpression of beclin inhibits Sindbis virus replication and expression of beclin lacking the Bcl-2 binding domain has no antiviral effects. Thus, beclin may be an important component of complexes involved in autophagy.

Western Blotting

TRUSTED_SUSTAINABILITY
Specifica

Specifica

Beclin
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Human Beclin aa. 171-291
50 μg
Cell Biology
Canine, Chicken, Human, Mouse, Rat
IgG2a
Western Blot
20
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
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