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CD19 Mouse anti-Human, PE-Cy7, Clone: SJ25C1, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 557835

Codice prodotto. 15889068

  • 915.00€ / Pezzo

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Descrizione

Descrizione

The SJ25C1 monoclonal antibody specifically binds to CD19, a B lymphocyte-lineage differentiation antigen. CD19, a 90-kDa transmembrance glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell through the mature B-cell stages. Terminally differentiated plasma cells do not express CD19. On the surface of mature B cells, the CD19 molecule associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to promote cellular activation. Studies with CD19-deficient mice have suggested that the level of CD19 expression affects the generation and maturation of B cells in the bone marrow and periphery. B-1 lineage B cells, also known as CD5+ B cells, are drastically reduced or absent in CD19-deficient mice. Increased levels of CD19 expression correlate with increased frequencies of peritonal and splenic B-1 cells and reduced numbers of conventional B lymphocytes in the periphery. CD19 participates in B-lymphocyte development, B-cell activation, maturation of memory B cells and regulation of tolerance. CD19 has also been detected on peritoneal mast cells, co-localized with CD21/CD35, and it is proposed to play a role in complement-mediated mast-cell activation.

TRUSTED_SUSTAINABILITY
Specifica

Specifica

CD19
Monoclonal
PE-Cyanine7
Mouse
Affinity Purified
RUO
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Flow Cytometry
SJ25C1
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Human NALM1 + NALM16 cells
100 Tests
Immunology
Human
IgG1 κ
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