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CDC42 Mouse, Unlabeled, Clone: 44, BD

Mouse Monoclonal Antibody

180.83€ - 342.40€

Specifica

Antigene CDC42
Clone 44
Concentrazione 250μg/mL
Applicazioni Western Blot
Classificazione Monoclonal
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Prodotti 2
Codice del prodotto Marca Quantità Prezzo Quantità e disponibilità  
Codice del prodotto Marca Quantità Prezzo Quantità e disponibilità  
15865709
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BD Biosciences
610928 		50 μg
ONLINE EXCLUSIVE PRICE
181.00€
180.83€ / 1 set
Risparmia 0.17€
0.09% Sconto
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15875709
Vedere i documenti
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BD Biosciences
610929 		150 μg
ONLINE EXCLUSIVE PRICE
343.00€
342.40€ / 1 set
Risparmia 0.60€
0.18% Sconto
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Descrizione

Descrizione

Rho family members are small GTP binding proteins that serve as molecular switches for a number of biological processes. They cycle between active GTP-bound and inactive GDP-bound states. CDC42 is a Rho family protein that was identified in membranes of human platelets and placenta. It is the homologue of CDC42Sc, which regulates initiation of bud-site assembly in Saccharomyces cerevisiae. CDC42 regulates the function of the mammalian actin cytoskeleton, allowing for efficient cytokinesis and cell morphogenesis. CDC42 and Rac1, a Ras-related GTPase, activate MEKK1, a JNK kinase kinase, which leads to the activation of several downstream components of the MAP kinase cascade leading to activation of PAK65, a CDC42- and Rac-binding protein. PAK65 interacts with CDC42/Rac1, mediates their interaction with MEKK1, and enhances MEKK1 catalytic activity. Chronic activation of CDC42 has been shown to induce malignant cellular transformation. Due to sequence homology among various small GTPase family members, potential cross-reactivity could be observed with this antibody. BD Pharmingen has not performed such cross-reactivity testing.

Immunofluorescence, Western Blotting

Specifica

Specifica

CDC42
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
44
Western Blot
Unconjugated
RUO
Canine, Human, Mouse, Rat
Human CDC42 aa. 1-191
Primary
Store undiluted at -20°C.
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For Research Use Only.

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