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E-Cadherin Mouse, FITC, Clone: 36/E-CADHERIN, BD
Mouse Monoclonal Antibody
Specifica
| Antigene | E-Cadherin |
|---|---|
| Clone | 36/E-CADHERIN |
| Concentrazione | 250μg/mL |
| Applicazioni | Immunofluorescence |
| Classificazione | Monoclonal |
Descrizione
E-Cadherin is a 120kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.
Immunofluorescence, Immunohistochemistry, Immunoprecipitation
Specifica
| E-Cadherin | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG2a κ | |
| Affinity Purified | |
| CD324; CDH1; CADH1; Cadherin-1; ECAD; CDHE; Arc-1; LCAM; UVO; Uvomorulin |
| 36/E-CADHERIN | |
| Immunofluorescence | |
| FITC | |
| RUO | |
| Canine, Human, Mouse, Rat | |
| Human E-Cadherin aa. 735-883 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.
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