missing translation for 'onlineSavingsMsg'
Learn More
Learn More
IL-17A Mouse anti-Human, Alexa Fluor 488, Clone: N49-653, BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 560489
Codice prodotto. 15880239
-
192.00€
191.53€ / Pezzo
Risparmia 0.47€
0.25% Sconto
Effettua il login per acquistare questo articolo Hai bisogno di un conto web ? Registrati oggi stesso!
Questo articolo non è restituibile.
Consulta la politica di reso
Descrizione
Human IL-17A, also known as IL-17, is a proinflammatory cytokine that is encoded by the IL17A gene in chromosome 6. IL-17A is produced as a disulfide-linked homodimer comprised of two mature 136-amino acid polypeptides. It is a member of the IL-17 family of structurally related cytokines, designated IL-17A through IL-17F. Activated memory T cells, especially Th17 cells (specialized IL-17A-producing CD4+ T cells distinct from Th1 and Th2 cells) produce IL-17 and provide protective immunity against pathogens. Activated CD8+ T cells, γδT cells, NK cells and neutrophils can also be activated to produce IL-17A. IL-17A binds to and exerts its biological activity through IL-17 receptors (IL-17R) that are expressed by a variety of target cells including fibroblasts, epithelial and endothelial cells, monocytes/macrophages and mast cells. The ubiquitous IL-17R expression pattern may explain the broad tissue responsiveness to IL-17. IL-17 induces stromal cells to secrete cytokines and chemokines involved in inflammatory and hematopoietic processes. For example, IL-17 induces fibroblasts to produce IL-6, IL-8, G-CSF and express increased surface ICAM-1. The N49-653 antibody reacts with human IL-17A.
Host Species: Mouse
Clone: N49-653
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Human IL-17A Recombinant Protein
Intracellular Staining
Specifica
| IL-17A | |
| Monoclonal | |
| Alexa Fluor 488 | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| Human IL-17A Recombinant Protein | |
| 25 Tests | |
| Immunology | |
| Human | |
| IgG1 κ |
| Flow Cytometry | |
| N49-653 | |
| IL-17; CTLA8; Cytotoxic T-lymphocyte-associated serine esterase 8 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
Correzione del contenuto del prodotto
Fornite il vostro feedback sul contenuto del prodotto compilando il modulo sottostante.
Titolo del prodotto
For Research Use Only.
Individuate un'opportunità di miglioramento?Condividi una correzione di contenuto