missing translation for 'onlineSavingsMsg'
Learn More
Learn More
IQGAP1 Mouse, Unlabeled, Clone: 24, BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 610611
Codice prodotto. 15885539
-
181.00€
180.83€ / 1 set
Risparmia 0.17€
0.09% Sconto
Effettua il login per acquistare questo articolo Hai bisogno di un conto web ? Registrati oggi stesso!
Questo articolo non è restituibile.
Consulta la politica di reso
Descrizione
GTPases (Ras, Rho, cdc42Hs, and rac) modulate various cellular functions such as cytoskeletal architecture, growth, motility, and gene expression. The activity of the GTP-binding proteins is regulated by factors that accelerate GTP-binding (GAPs) and proteins that enhance the rate of GTP hydrolysis (GTPases). IQGAP1 is Ras-GAP related protein that contains a WW domain that binds poly-proline regions, a calponin-homology domain (CHD), an IQ domain of unconventional myosins, and a C-terminal GAP-related domain (GRD). IQGAP1 co-immunoprecipitates with cdc42 and calmodulin, and colocalizes with cdc42Hs at the leading edges of the plasma membrane and at the cell-cell junctions. IQGAP1 may interact with both cadherins and catenins leading to dissociation of these proteins from sites of cell adhesion. Thus, IQGAP1 may be a Rac1 and Cdc42 effector that negatively regulates cadherin-mediated cell junctions.
Specifica
| IQGAP1 | |
| Monoclonal | |
| 250μg/mL | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| 50 μg | |
| Cell Biology | |
| Canine, Human, Mouse, Rat | |
| IgG1 |
| Western Blot | |
| 24 | |
| Unconjugated | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at -20°C. |
Correzione del contenuto del prodotto
Fornite il vostro feedback sul contenuto del prodotto compilando il modulo sottostante.
Titolo del prodotto
For Research Use Only.
Individuate un'opportunità di miglioramento?Condividi una correzione di contenuto