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Ras Mouse, Unlabeled, Clone: 18, BD
Mouse Monoclonal Antibody
343.00€ - 673.00€
Specifica
Antigene | Ras |
---|---|
Clone | 18 |
Concentrazione | 250μg/mL |
Applicazioni | Western Blot |
Classificazione | Monoclonal |
Codice del prodotto | Marca | Quantità | Prezzo | Quantità e disponibilità | |||||
---|---|---|---|---|---|---|---|---|---|
Codice del prodotto | Marca | Quantità | Prezzo | Quantità e disponibilità | |||||
10074553
|
BD Biosciences
610001 |
50 μg |
343.00€
Pezzo |
Spedizione stimata: 15-05-2024 Eseguire il login per visualizzare lo stock disponibile |
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15825209
|
BD Biosciences
610002 |
150 μg |
Questo articolo non è attualmente disponibile o è stato dismesso. La preghiamo di consultare la pagina del prodotto per individuare le possibili alternative. |
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Descrizione
Ras and related proteins of the Ras superfamily play critical roles in the control of normal and neoplastic proliferation. In mammalian cells there are four true Ras proteins (encoded by Ha- ras , N- ras , Ki- ras A, and Ki- ras B ) which, upon mutational activation, can function as independent oncogenes. These proteins relay signals from tyrosine kinases at the plasma membrane which subsequently lead to the nucleus via a network of serine/threonine kinases . The p21ras protein is active in its GTP-bound state. This form is slowly converted to the GDP-bound form by the intrinsic GTPase activity of Ras. This activity is greatly enhanced byGTPase-activating proteins (GAPs) which subsequently lead to removal of the GTP molecule and replacement with GDP. Maintenance of Ras in the GTP form can lead to transformation. One class of Ras mutations, commonly found in human tumors, results in an accumulation of Ras-GTP. The mutant Ras can bind GAP, but GAP bound in this manner seems unable to affect the Ras-GTPase activity.Specifica
Ras | |
250μg/mL | |
Monoclonal | |
Mouse | |
Cell Biology | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
IgG1 κ | |
Affinity Purified |
18 | |
Western Blot | |
Unconjugated | |
RUO | |
Canine, Chicken, Human, Mouse, Rat | |
Human Ras (Ha-ras) aa. 1-190 | |
Primary | |
Store undiluted at -20°C. |
For Research Use Only.