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SHC Mouse, Unlabeled, Clone: 30, BD
Mouse Monoclonal Antibody
170.13€ - 454.75€
Specifica
| Antigene | SHC |
|---|---|
| Clone | 30 |
| Concentrazione | 250μg/mL |
| Applicazioni | Western Blot |
| Classificazione | Monoclonal |
| Codice del prodotto | Marca | Quantità | Prezzo | Quantità e disponibilità | |||||
|---|---|---|---|---|---|---|---|---|---|
| Codice del prodotto | Marca | Quantità | Prezzo | Quantità e disponibilità | |||||
|
15825689
|
BD Biosciences
610878 |
50 μg |
 171.00€ 170.13€ / 1 set Risparmia 0.87€ 0.51% Sconto |
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|
15835689
|
BD Biosciences
610879 |
150 μg |
455.00€ 454.75€ / 1 set Risparmia 0.25€ 0.06% Sconto |
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Descrizione
The mammalian SHC proteins, which are expressed as multiple isoforms (46, 52, and 66kDa), each contain a C-terminal SH2 domain and an N-terminal glycine/proline rich sequence. These proteins function as early signaling intermediates (also called adaptor proteins) which relay G protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK)-induced signals via the Ras transduction pathway. To this end, the SHC proteins contain specific tyrosine residues which are phosphorylated following association with the active RTKs.
Phosphorylated SHC forms a complex with the adaptor protein GRB2. Association of the SHC-GRB2 complex with the Ras guanine nucleotide exchange factor (Ras-GEF) mediates the localization of Ras-GEF to the plasma membrane. Once at the plasma membrane, Ras-GEF activates Ras by catalyzing the Ras-GTP for Ras-GDP exchange. Over-expression of SHC results in cell transformation, and phosphorylation of SHC correlates with activation of the ERK1/ERK2 kinases. The SHC proteins are mediators of signals that are essential
for cell metabolism, growth, and differentiation.
Immunofluorescence, Western Blotting
Specifica
| SHC | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified |
| 30 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Canine, Chicken, Human, Mouse, Rat | |
| Human SHC aa. 359-473 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.
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