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ASAH1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 11274-1-AP-150UL

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 16898233

  • 325.38€ / 150µL

Spedizione stimata: 11-10-2022
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Descrizione

Descrizione

Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH1 is an acid ceramidase and key regulator of ceramide metabolism. Mutations in this gene results in Farber Lipogranulomatosis, a fatal human genetic disorder that results in the painful swelling of the joints and tendons and pulmonary insufficiency, while a complete knockout of its expression is lethal in mice. Recent studies have shown elevated levels of ASAH1 in Alzheimer′s disease (AD) patients correlating with a reduction in sphingomyelin and elevation of ceramide. Pretreatment of cultured neurons with recombit AHAH1 prevented the cells from undergoing A-beta (Ab)-induced apoptosis. Multiple isoforms of this protein are known to exist.
Specifica

Specifica

ASAH1
Polyclonal
Unconjugated
ASAH1
AC, Acid ceramidase, Acylsphingosine deacylase, ASAH, ASAH1, HSD 33, PHP, PHP32, Putative 32 kDa heart protein
Rabbit
Antigen Affinity Chromatography
RUO
11886, 427, 84431
-20°C
Liquid
Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry
0.15 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q13510, Q6P7S1, Q9WV54
Asah1
ASAH1 Fusion Protein Ag1799
150 μL
Primary
Rat, Mouse, Human
Antibody
IgG
Videos
SDS
Documenti
Certificati
Offerte speciali

Offerte speciali