Invitrogen™ C5AR1 Monoclonal Antibody (8D6), Biotin

Descrizione

MA5-17740 targets C5a receptor/CD88 in FACS applications and shows reactivity with Human samples. The MA5-17740 immunogen is rBL-2H3 (rat basophilic leukemia) transfected cells expressing human C5aR on the cell surface.

CD88, also known as C5aR1, is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known. C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release and superoxide anion production. CD88 is also a component of the classical pathway of the complement cascade; it may be involved with tissue injury associated with ischemia or sepsis and it may be a component of the membrane attack complex. Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.