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CD2 Mouse anti-Human, Clone: 3A10B2, Proteintech

Mouse Monoclonal Antibody

140.00€ - 399.00€

Specifica

Antigene CD2
Clone 3A10B2
Concentrazione 1 mg/mL
Applicazioni Immunohistochemistry (Paraffin), Western Blot
Classificazione Monoclonal
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Prodotti 2
Codice del prodotto Marca Quantità Prezzo Quantità e disponibilità  
Codice del prodotto Marca Quantità Prezzo Quantità e disponibilità  
16806965
Vedere i documenti Dettagli della promozione
Proteintech
60005-1-IG-20UL
20 μL
140.00€
20µL
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Spedizione stimata: 16-04-2024
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16896955
Vedere i documenti Dettagli della promozione
Proteintech
60005-1-IG-150UL
150 μL
399.00€
150µL
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Spedizione stimata: 16-04-2024
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Descrizione

Descrizione

CD2 (LFA-2) is a monomeric surface antigen (MW range 45-58 kDa) of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells. CD2 is one of the earliest T-cell markers, being present on more than 95% of thymocytes and it is also found on some natural killer cells, but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it. The interaction between CD2 and CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection. Diseases associated with CD2 dysfunction include penis squamous cell carcinoma and immune deficiency due to the absence of the thymus.
Specifica

Specifica

CD2
1 mg/mL
Monoclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
CD2, CD2 molecule, Erythrocyte receptor, LFA 2, LFA 3 receptor, Rosette receptor, SRBC, T cell surface antigen CD2, T11
CD2
IgG1
Protein G
Antibody
3A10B2
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
Mouse
Human
P06729
914
CD2 Fusion Protein Ag0423
Primary
-20°C
CD2
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Documenti

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