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CD71 Mouse anti-Human, Clone: 3C11F11, Proteintech

Mouse Monoclonal Antibody

Marca:  Proteintech 66180-1-IG-150UL

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 16897815

  • 325.38€ / 150µL

Spedizione stimata: 11-10-2022
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Descrizione

Descrizione

Transferrin Receptor (CD71) is a type II transmembrane disulfide-bonded glycoprotein expressed as homodimer in erythroid blood cell line and activated leukocytes. The ligand for Transferrin Receptor is the serum iron transport protein, transferrin. Upon binding holotransferrin (complex of transferrin and iron ions), Transferrin Receptor is internalized by clathrin-mediated endocytosis. Acidification of endosomes by vesicular membrane proton pumps leads to dissociation of iron ions, whereas transferrin (apotransferrin) remains associated with Transferrin Receptor and recycles to the cell surface, where it is released upon exposure to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin Receptor is also involved in uptake of non-transferrin bound iron. Transferrin Receptor is necessary for development of erythrocytes and the nervous system. Serum Transferrin Receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from conditions including rheumatoid arthritis, pregcy, irritable bowel syndrome and HIV infection. Transferrin Receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in maligcies such as breast cancer.
Specifica

Specifica

CD71
Monoclonal
1.8 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P02786
TFRC
CD71 Fusion Protein Ag21612
150 μL
Primary
Human
Antibody
IgG2a
Immunoprecipitation, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry, Flow Cytometry
3C11F11
Unconjugated
TFRC
CD71, p90, sTfR, T9, TFR, TFR1, TFRC, TR, Transferrin receptor protein 1, TRFR
Mouse
Protein A
RUO
7037
-20°C
Liquid
Videos
SDS
Documenti
Certificati
Offerte speciali

Offerte speciali