Invitrogen™ CDH17 Polyclonal Antibody

Descrizione

Immunogen sequence: GTKVGNVTAK DPEGLDISYS LRGDTRGWLK IDHVTGEIFS VAPLDREAGS PYRVQVVATE VGGSSLSSVS EFHLILMDVN DNPPRLAKDY T Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 80%.

CDH17 gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants.