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Invitrogen™ CYR61 Polyclonal Antibody
Sheep Polyclonal Antibody
Marca: Invitrogen™ PA5149113
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Descrizione
Reconstitute at 0.2 mg/mL in sterile PBS.
CYR61 is a secreted heparin binding protein, encoded by a growth factor inducible immediate-early gene that associates with the extracellular matrix and connective tissue. CYR61 is a member of a distinct family of angiogenic and vasculogenic regulators designated CCN proteins, which includes connective tissue growth factor (CTGF) and the mouse CYR61 homolog, Fisp12. As an angiogenic inducer, CYR61 binds to the cell surface receptor integrin alphavbeta3, where it then stimulates cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells. Expression of CYR61 is elevated during vessel growth, wound healing and chondrocyte differentiation. CYR61 is also detected in a wide variety of tumors as it induces tumor growth and functions as a marker of tumor progression.
Specifica
| CYR61 | |
| Polyclonal | |
| Unconjugated | |
| CCN1 | |
| 3CH61; AI325051; CCN family member 1; CCN1; cellular communication network factor 1; Cyr61; cysteine rich angiogenic inducer 61; cysteine rich protein 61; cysteine-rich angiogenic inducer 61; cysteine-rich heparin-binding protein 61; cysteine-rich, angiogenic inducer, 61; cysteine-rich, anigogenic inducer, 61; GIG1; IBP-10; IGF-binding protein 10; IGFBP10; IGFBP-10; insulin-like growth factor binding protein 10; insulin-like growth factor-binding protein 10; intermediate early; protein CYR61; Protein GIG1 | |
| Sheep | |
| Antigen affinity chromatography | |
| RUO | |
| 3491 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
| ELISA, Western Blot | |
| 0.2 mg/mL | |
| PBS with trehalose and no preservative | |
| O00622 | |
| CCN1 | |
| Mouse myeloma cell line NS0-derived recombinant human Cyr61/CCN1, Ala22-Asp381. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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