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Invitrogen™ Epstein Barr Virus Nuclear Antigen 1 Polyclonal Antibody
Goat Polyclonal Antibody
Marca: Invitrogen™ PA17497
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Descrizione
The PA1-7497 antibody detects Epstein-Barr nuclear antigen (EBNA-1). PA1-7497 has been successfully used in ELISA. Potential applications for PA1-7497 include fluorescence microscopy and immunohistochemistry. The PA1-7497 antibody was raised against recombinant EBNA-1.
Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkin's disease and Burkitt's Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all malignancies associated with EBV.
Specifica
| Epstein Barr Virus Nuclear Antigen 1 | |
| Polyclonal | |
| Unconjugated | |
| EBNA-1 | |
| Recombinant EBNA-1. | |
| 1 mL | |
| Primary | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| ELISA, Western Blot | |
| 5 mg/mL | |
| PBS with 0.1% sodium azide; pH 7.2 | |
| Goat | |
| IgG fraction | |
| RUO | |
| Virus | |
| Antibody | |
| IgG |
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