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Invitrogen™ Factor X/Xa Monoclonal Antibody (5051)
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Codice prodotto. 11529862
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Quantità:
100 μg
Dimensione della confezione:
100µg
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Codice prodotto. Quantità unitSize
11529862 100 μg 100µg
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Codice prodotto. 11529862 Fornitore Invitrogen™ N. del fornitore MA143014

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Descrizione

Mouse Monoclonal Antibody

This antibody detects the heavy chain of bovine Factor X and Xa, BEGRck factor Xa. It will cross-react with human, rabbit, sheep, porcine and canine factor X. This antibody does not recognize murine Factor X via Western blot. Inhibitory properties: inhibitory in clotting assay (APTT and PT), partial calcium dependence. Dissociation Constant: Kd = 9X10^(-11)M. Purity >95% by SDS-PAGE.

Factor X undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.
TRUSTED_SUSTAINABILITY

Specifica

Antigene Factor X/Xa
Applicazioni Affinity Purification, Inhibition Assays, Radioimmune Assays (RIA), Western Blot
Classificazione Monoclonal
Clone 5051
Concentrazione 8.4 mg/mL
Coniugato Unconjugated
Formulazione 50% water with 50% glycerol and no preservative
Gene F10
N. accesso geni O19045, P00742, P00743
Alias gene Activated factor Xa heavy chain; blood coagulation factor X; Cf10; coagulation factor 10; coagulation factor X; coagulation factor X protein; F10; Factor X heavy chain; Factor X light chain; factor Xa; FX; FXA; prothrombinase; stuart factor; Stuart-Prower factor; Unknown (protein for IMAGE:8121240); unnamed protein product
Simboli geni F10
Specie ospite Mouse
Immunogeno Purified bovine Factor X.
Metodo di purificazione SDS-PAGE
Quantità 100 μg
Status giuridico RUO
Primario o secondario Primary
ID gene (immissione) 100008647, 101118624, 2159, 280787, 476993, 733662
Target Species Human, Canine, Rabbit, Bovine, Sheep, Pig
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Forma Liquid
Isotype IgG1
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