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Invitrogen™ Factor X/Xa Monoclonal Antibody (GT268)

Descrizione
Keep as concentrated solution. Predicted reactivity: Rhesus Monkey (93%). Positive Control: human F10-transfected 293T cells. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Factor X undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.
Specifica
Specifica
| Antigene | Factor X/Xa |
| Applicazioni | Western Blot, Immunocytochemistry |
| Classificazione | Monoclonal |
| Clone | GT268 |
| Concentrazione | 1 mg/mL |
| Coniugato | Unconjugated |
| Formulazione | PBS with no preservative |
| Gene | F10 |
| N. accesso geni | P00742 |
| Alias gene | Activated factor Xa heavy chain; blood coagulation factor X; Cf10; coagulation factor 10; coagulation factor X; coagulation factor X protein; F10; Factor X heavy chain; Factor X light chain; factor Xa; FX; FXA; prothrombinase; stuart factor; Stuart-Prower factor; Unknown (protein for IMAGE:8121240); unnamed protein product |
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