FOXP2 Monoclonal Antibody (5C11A2), Invitrogen™

Descrizione

MA5-15904 targets FOXP2 in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15904 immunogen is purified recombinant fragment of human MAPK3 expressed in E. Coli. . MA5-15904 detects FOXP2 which has a predicted molecular weight of approximately 85kDa.

FOXP2 is a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may μgtimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.