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HDAC9 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Marca:  Invitrogen PA511245

Dettagli aggiuntivi : Peso : 0.01000kg

Codice prodotto. 10008739

  • 514.00€ / 400µL
Spedizione stimata: 05-06-2024
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Descrizione

Descrizione

This antibody is predicted to react with chicken and mouse based on sequence homology.

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is a critical component of transcriptional regulation and the acetylation of nucleosomal histones is a major source of this remodeling. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Several mammalian proteins function as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Conversely, the deacetylation of histones is associated with transcriptional silencing. The histone deacetylases (HDAC) include HDAC1-9. HDAC9 and HDAC9a are two alternatively spliced isoforms of HDAC9. HDAC9a is 132 amino acids shorter than HDAC9, but both isoforms contain the HDAC catalytic domain, remain capable of deacetylase activity and repress myoctye enhancer-binding factor 2-mediated transcription. HDAC9 and HDAC9a are expressed in brain, skeletal muscle, kidney, placenta and pancreas.
Specifica

Specifica

HDAC9
Polyclonal
Unconjugated
Hdac9
AV022454; D030072B18Rik; DKFZp779K1053; HD7; HD7b; HD9; HDAC; HDAC7; Hdac7b; HDAC9; hdac-9; HDAC9B; HDAC9FL; HDRP; histone deacetylase 4/5-related protein; histone deacetylase 7B; Histone deacetylase 9; histone deacetylase-related protein; KIAA0744; MEF-2 interacting transcription repressor (MITR) protein; MEF2-interacting transcription repressor MITR; Mitr; mKIAA0744; RGD1310748; RGD1563092; TWIST
Rabbit
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
79221, 9734
-20° C, Avoid Freeze/Thaw Cycles
Liquid
ChIP Assay, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
2 mg/mL
PBS with 0.09% sodium azide
Q99N13, Q9UKV0
Hdac9
KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human HDAC9
400 μL
Primary
Human, Mouse
Antibody
IgG
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