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ACROBiosystems Human CD3 gamma / CD3G Protein, Fc Tag (MALS verified)

Marca:  ACROBiosystems CDA-H5254-1mg

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 17276120

  • 3329.77€ / 1mg
Spedizione stimata: 06-03-2024
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Descrizione

Descrizione

CD3 gamma chain is part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 37.1 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifica

Specifica

AAI13831.1
1 mg
Gln 23 - Ser 116
CD3G,CD3-GAMMA,IMD17,T3G,TCR gamma
Unconjugated
Fc Tag
Less than 1.0 EU / µg by the LAL method.
Powder
>95% as determined by SDS-PAGE.
37.1 kDa
Human CD3 gamma, Fc Tag (CDA-H5254) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - Ser 116 (Accession # P09693-1).
-20°C
CD3 gamma
Human
PBS, pH7.4
HEK293
Bio-Markers & CD Antigens
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