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Invitrogen™ IA-1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA520823
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Descrizione
A suggested positive control is rat thymus tissue lysate. PA5-20823 can be used with blocking peptide PEP-0937.
IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.
Specifica
| IA-1 | |
| Polyclonal | |
| Unconjugated | |
| INSM1 | |
| IA1; IA-1; INSM transcriptional repressor 1; Insm1; insulinoma associated 1; insulinoma-associated 1; insulinoma-associated protein (IA-1); insulinoma-associated protein 1; insulinoma-associated protein 1-like; LOC100912563; Zinc finger protein IA-1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 100912563, 3642, 53626 | |
| Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| PBS with 0.02% sodium azide | |
| Q01101, Q63ZV0 | |
| INSM1 | |
| A 19 amino acid peptide from near the amino terminus of human IA-1. | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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