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IDH1 Mouse anti-Human, Clone: IDH1/1152, Abnova™

Mouse monoclonal antibody raised against partial recombinant human IDH1.

Marca:  Abnova MAB13318.100ug

Codice prodotto. 16061846

  • 503.00€ / 100µg

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Descrizione

Descrizione

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq]

Specifica

Specifica

IDH1
Monoclonal
Unconjugated
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) Western Blot (0.5-1 ug/mL) The optimal working dilution should be dete
IDCD/IDH/IDP/IDPC/PICD
Mouse
Protein A/G purification
RUO
3417
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing.
IgG1 κ
Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
IDH1/1152
Mouse monoclonal antibody raised against partial recombinant human IDH1.
In 1mM PBS.
IDH1
Recombinant protein corresponding to 119 residues around amino acids 280-420 of human IDH1.
100 μg
Primary
Human
Liquid
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