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IRAK-M Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA519969
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Descrizione
In Western blot applications, this antibody detects a band at ∽68kDa. A suggested positive control is mouse spleen tissue lysate. PA5-19969 can be used with blocking peptide PEP-0094.
IRAK3 serine/threonine kinase or interleukin-1 receptor-associated kinase 3 is a member of the interleukin-1 receptor-associated kinase protein family which are essential components of the Toll/IL-R immune signal transduction pathways. IRAK3 is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. IRAK3 mediates critical aspects of innate immunity that result in an immunocompromised state during sepsis. Mutations in IRAK3 are associated with a susceptibility to asthma.
Specifica
| IRAK-M | |
| Polyclonal | |
| Unconjugated | |
| IRAK3 | |
| 4833428C18Rik; AI563835; ASRT5; FLJ13601; IL-1 receptor-associated kinase M; interleukin 1 receptor associated kinase 3; interleukin-1 receptor-associated kinase 3; IRAK3; IRAK-3; IRAKM; IRAK-M | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 11213, 314870, 73914 | |
| Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C | |
| Liquid |
| Immunocytochemistry, Immunohistochemistry, Western Blot | |
| 1 mg/mL | |
| PBS with 0.02% sodium azide | |
| Q8K4B2, Q9Y616 | |
| IRAK3 | |
| A peptide corresponding to 16 amino acids from the carboxy terminus of human IRAK-M. | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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