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IRAK1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA519855
340.01 EUR valido fino al 2025-03-29
Usa il codice promo "24111" per avere il tuo prezzo promozionale.
Allerta:
To receive the discount customers must purchase three of the same product at list price in a single order to receive 33% discount. There is no limit to the multiples of 3 that customers can buy. Use promo code ”24111” to get your promotional price
Descrizione
A suggested positive control is Hela cell lysate. PA5-19855 can be used with blocking peptide PEP-0001.
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK's association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus. This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state.
Specifica
| IRAK1 | |
| Polyclonal | |
| Unconjugated | |
| Irak1 | |
| AA408924; Il1rak; interleukin 1 receptor associated kinase 1; interleukin-1 receptor-associated kinase 1; interleukin-1 receptor-associated kinase-1; IRAK; Irak1; IRAK-1; IRAK1-S; mPLK; pelle; Pelle homolog; pelle-like protein kinase; Plpk; RGD1563841 | |
| Rabbit | |
| Anitgen affinity chromatography | |
| RUO | |
| 16179, 363520, 3654 | |
| Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C | |
| Liquid |
| Immunocytochemistry, Immunoprecipitation, Western Blot | |
| 1 mg/mL | |
| PBS with 0.02% sodium azide | |
| P51617, Q62406 | |
| Irak1 | |
| A peptide corresponding to amino acids near the carboxy terminus of human IRAK. | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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