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Eurofins DiscoverX MAP Kinase 1/Erk1 Protein, Active
Descrizione
ERK1 (extracellular signal-regulated protein kinase) is one of the isoforms of MAP kinase. This 42 kD serine/threonine kinase is activated by dual phosphorylation on tyrosine and threonine residues. Phosphorylation of both residues by the upstream activator MEK is essential not only for ERK1 activation but also for translocation of the ERK1 to the nucleus. Following this activation, ERK1 phosphorylates a large number of regulatory proteins and this directly controls key cellular processes such as transcription, translation and cytoskeletal rearrangement. An inhibitor assay may be of benefit for the treatment of cancer, diabetes, neurodegenerative disorders or asthma.
GenBank XM_055766
Specifica
Specifica
| Formulazione | mg/mL of enzyme in 20 mM MOPS/NaOH pH 7.2, 25 mM sodium-b-glycerophosphate, 5 mM EGTA, 1 mM sodium orthovanadate, 1 mM dithiothreitol, 50 % glycerol. |
| Peso molecolare | 69.9 kDa |
| Quantità | 250 μg |
| Specie | Human |
| Recombinant | Recombinant |
| Tag proteine | N-terminal GST |
| Sistema di espressione | Recombinant enzyme expressed in E.coli cells |
| Protein Form | Full-length |
| Purity or Quality Grade | ≥76% |
| Proteine | MAP kinase 1, active |
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