MEK6 Monoclonal Antibody (3H12B9), Invitrogen™

Descrizione

MA5-15809 targets MAP2K6 in indirect ELISA, IHC and WB applications and shows reactivity with Human and mouse samples. The MA5-15809 immunogen is purified recombinant fragment of human MAP2K6 expressed in E. Coli. MA5-15809 detects MAP2K6 which has a predicted molecular weight of approximately 38kDa.

MKK6 (MEK6, MAP2K6) is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. Tissue specificity: Isoform 2 is only expressed in skeletal muscle. Isoform 1, on the other hand, is found in skeletal muscle, heart, and in lesser extent in liver or pancreas.